Who are the Villains in Marvel's Spider-Man 2?

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GameVillage Team
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Check out our guide to find who you'll will face in Marvel's Spider-Man 2! As one of the most popular superheroes, its fame comes with formidable villains.

Spider-Man-2-Villains

SPOILER ALERT
The following contains major spoilers for the villains of Marvel's Spider-Man 2. If you want to find out who all the villains are on your own, go back now!

Tombstone

Tombstone

Real Name Voiced by
Lonnie Lincoln Corey Jones

Level Encountered in “Hunt to Live, Live to Hunt” side mission.
A long-time antagonist to Spider-Man, Tombstone was present in Marvel's Spider-Man 1 as a villain, but the large stone-faced man makes a return in Spider-Man 2 as a reformed villain in one of the game's side quests.

Chameleon

Chameleon

Voiced by
Dmitri Smerdyakov Jim Pirri

Encountered during the “Unidentified Targets” Side Quest chain
A master of disguise and one of Spider-Man's toughest shape-shifting villains. Chameleon makes a surprising return and is revealed to be Kraven's half-brother.

Mister Negative

Mister Negative

Real Name Voiced by
Martin Li Stephen Oyoung

Encountered during the “No Escape” Mission.
As one of the main villains of Spider-Man 2018, Mister Negative's memorable presence as the unassuming Martin Li makes a comeback in Spider-Man 2 as a boss battle in all his dark and pale haired glory.

Cletus Kasady

Cletus Kasady

Real Name Voiced by
Cletus Kasady Chad Doreck

While not present as Carnage. He is Encountered during “The Flame” Side mission chain
Cletus Kasady is memorable as the red symbiote user Carnage. But in Spider-Man 2 he does not make an appearance as the iconic Venom counterpart, instead appearing as the red-haired cult leader of The Followers of The Flame.

The Lizard

The Lizard

Real Name Voiced by
Curt Connors Mark Whitten

Encountered in the level “New Threads”.
Having one of the more tragic origins of Spider-Man's rogue's gallery, the reptilian menace appears as a boss battle where he takes on Spider-Man where his Crocodilian features make him a brutal challenge.

Mysterio

Mysterio

Real Name Voiced by
Quentin Beck Noshir Dalal

Encountered in the “Master Illusionist” mission.
Memorable for his globe helmet, misleading tactics and illusionary powers, Mysterio appears in Spider-Man 2 in a side-quest that involves Spider-Man helping Quentin Beck with a virtual reality virus.

Sandman

Sandman

Real Name Voiced by
Flint Marko Leandro Cano

Encountered in the “Surface Tension” mission.
As one of Spider-Man's more sympathetic but gigantic villains, Sandman's boss encounter will have players dealing with his truly terrifying abilities.

Venom

Venom

Real Name Voiced by
Harry Osborn Tony Todd

First encountered in “Don’t Be Scared” as Harry Osborn. Eddie Brock does not appear in Marvel's Spider-Man 2.
Developed as a dark counterpart to Spider-Man, Venom in the comics first appeared with Eddie Brock as its host. But in a surprising twist, Spider-Man 2 uses Peter Parker's childhood friend Harry Osborn instead as the symbiote's host.

The Scorpion

The Scorpion

Real Name Voiced by
Mac Gargan Jason Spisak

Revealed in the “Not On My Watch” mission during a cutscene.
The Scorpion's origin in the game is drastically different from his private investigator counterpart in the comics. Instead, he is a fiercer, more intimidating villain in Spider-Man 2 while still keeping the scorpion tail and suit. Though the player won't be fighting him, he has a few memorable cutscenes.

Wraith

Wraith

Real Name Voiced by
Yuriko Watanabe Tara Platt

Encountered during “The Flame” series of side missions.
Wraith is a police officer who also moonlights as the ninja vigilante. Though not a true villain in terms of alignment, Wraith is antagonistic to Spider-Man and even faces Peter Parker in a boss battle. But ends up helping him in the end.

Scream

Scream

Real Name Voiced by
Mary Jane Watson Laura Bailey

Revealed as Scream and taken on as a Boss fight in “This isn't You” Main Mission.
Spider-Man 2's Scream has a unique twist on the character, who is normally a Venom villain. As one of Venom's “children”, the red and yellow symbiote possesses Mary Jane Watson, forcing Peter Parker to face her in a boss battle where he eventually frees her.

Symbiote Spider-Man/Black-Suit Peter

Symbiote Spider-Man/Black-Suit Peter

Real Name Voiced by
Peter Parker Yuri Lowenthal

First as a playable character but later on as an eventual boss fight, Symbiote Spider-Man will be battled during the “Anything Can Be Broken” Side Mission with the player controlling Miles Morales.
Despite giving Peter Parker enhanced strength and other abilities, the Symbiote Spider-Man suit eventually turns violent by tapping into Peter Parker's darker impulses, forcing Miles Morales to battle him.

Doctor Octopus

Doctor Octopus

Real Name Voiced by
Otto Octavius William Salyers

Revealed in a Post Credits cinematic.
One of the main villains of Spider-Man 1, Doctor Octopus, makes a reveal, possibly teasing a future role as the Master Planner in the game's possible sequels.

Kraven the Hunter

Kraven the Hunter,

Real Name Voiced by
Sergei Kravinoff Jim Pirri

Revealed in the Opening Cinematic and as one of the game's main villains.
Dressed in furs and leading an army of hunters. Kraven has the most imposing presence among all the game's enemies, where he forces Peter Parker to question his own ethics as a superhero. Preferring to hunt with his bare hands, Kraven will be a worthy challenge for players who want a visceral Spider-Man experience.