Resident Evil 4: Boss Fight Strategy

List of Story Bosses

Boss	Chapter/Defeating Method
Chainsaw Man	Chapter 1・Attack the head and make it stagger ・Defend against swinging attacks with the Knife ・Dodge the instant death charge attack by running
Del Lago	Chapter 3・Learn the attack patterns ・Dodge the attacks from underwater to the right ・Throw the harpoon if available
El Gigante	Chapter 4・Aim for the face and bring it down ・Attack the weak points ・The area around its feet is a safe zone
Mendez	Chapter 6・Aim for the eyeball on his back ・When he takes an explosive barrel, shoot the barrel ・Dodge the throwing attacks by keeping distance
Verdugo	Chapter 10・Dodge the tail attacks ・Freeze it with liquid nitrogen ・Attack the frozen parts
Armored El Gigante	Chapter 11・Defeat the regular El Gigante first ・Destroy the armor with dynamite ・Attack the weak points
Krauser	Chapter 11・Parry with the Knife for a counterattack ・Dodge melee attacks ・Attack with the Knife between its attacks
Salazar	Chapter 13・Aim for the main body inside ・Destroy the acid balls on the ground ・Dodge the instant death bite attack
Krauser (Transformed)	Chapter 14・Parry the attack from its left hand ・Remember the locations with traps along the way
Saddler	Chapter 16・Destroy the eyeballs on its legs ・Attack with the Knife after it's down ・Take out the spawning Novistadors as needed
Saddler (Transformed)	Chapter 16・Dodge the tentacle attacks ・Attack the eyeballs ・Pick up the Rocket Launcher

Troubleshoot if Unable to Defeat the Boss

Upgrade Your Weapon

If you're unable to defeat the boss, try upgrading your weapon. Upgrading your weapon will improve its rate of fire and power, allowing you to defeat enemies more smoothly than before. Make sure to regularly upgrade your weapon at the Merchant's shop.

Carry Extra Recovery Items in Your Attache Case

If you can't defeat the boss, it's recommended to carry extra recovery items such as herbs and First Aid Spray. Since there is a limit to the number of items that can be placed in the attache case, only focus on useful weapons, ammo, and recovery items, and leave unused weapons and ammo behind. After that, challenge the boss again.

Focus on Attacking the Enemy's Weak Points

To efficiently attack the boss, it is essential to target their weak points. Since the weak points vary for each boss, observe the enemy's reaction and effects when your attacks hit. Focus on attacking the parts where you can deal the most damage.

Main Story Bosses
Armored El Gigante	Chainsaw Man
Del Lago	El Gigante
Mendez	Garrador
Verdugo	Krauser
Salazar	Saddler

Strong Threat
How to Obtain the Two Bugs, One Stone Trophy