Resident Evil 4: Chapter 16: Walkthrough

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GameVillage Team
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Complete guide to Chapter 16 in Resident Evil 4 Remake: solving puzzles, defeating bosses, and item tips.

Bio re4_Chapter 16

Chapter 15 After Clear

Steps to Complete Chapter 16

Steps to Clear until the Ending
1 Lower the ladder with Ashley's help
2 Proceed straight on Sanctuary
3 Prepare for the final battle at the Merchant
4 Defeat the final boss, Saddler
5 Escape from the island within the time limit

Lower the Ladder with Ashley's Assistance

Lower the ladder with Ashley's help

Once Chapter 16 starts, team up with Ashley to lower the ladder. After that, proceed directly to the Sanctuary.

Head Straight Through the Sanctuary

Proceed straight on Sanctuary

Upon reaching the Sanctuary, continue straight ahead. Be sure to pick up the "Iluminados Pendant" along the way.

Gear Up for the Final Battle at the Merchant

Proceed deeper and prepare for the final battle

After leaving the Sanctuary, you'll encounter the Merchant. Stock up on powerful weapons like a rapid-fire Sniper Rifle or a Rocket Launcher to better tackle the final boss.

Defeat the Final Boss Saddler

Defeating the final boss Saddler

After talking to the Merchant, a cutscene will initiate the final battle with Saddler. Aim for his eye to weaken him, then close in and use the Knife for heavy damage.

Exit the Island Within the Time Limit

Escaping from the island within the time limit

Once you've defeated Saddler, make your way off the island before time runs out. The enemies you encounter will be incapacitated, so you can safely ignore them.

Navigate the Boat Safely

As you board the boat, accelerate and keep moving. If an obstacle is in your path, slow down and maneuver around it. Successfully leaving the island within the allotted time means you've completed the game.

How to Obtain the Smooth Escape Trophy

Final Boss Strategy

Tips for defeating the final boss
Focus on attacking the eyeballs on the joints
When it's down, get close and finish it off with the Knife
Shoot the nearby cans to make them explode
Defeat the second form with the Rocket Launcher obtained from Ada

Focus on attacking the eyeballs on the joints

Focus on attacking the eyeballs on the joints

In the final boss battle, concentrate your attacks on the eyeballs on its leg joints. Breaking one eyeball will momentarily stagger it, and breaking two or more will cause it to go down, giving you a chance to deal massive damage.

When it's down, get close and finish it off with the Knife

When it's down, get close and finish it off with the Knife

When the final boss is down, approach it and press the R2 button to inflict heavy damage with the Knife. If you manage to down it from a distance, it's recommended to aim for the long frontal eyeball section.

Shoot the nearby cans to make them explode

Shoot the nearby cans to make them explode

If there are cans near the final boss, shoot them to make them explode. Hitting the boss with the explosion will stagger it, allowing you to attack the vulnerable eyeballs at the back more efficiently.

Defeat the second form with the Rocket Launcher obtained from Ada

Defeat the second form with the Rocket Launcher obtained from Ada

When the final boss transforms into its second form, it will launch multiple attacks, so use the ◯ button to dodge. As time passes, Ada will throw you a Rocket Launcher, so aim for the central sphere and shoot to complete the strategy.

Strategy and Behavior Patterns for the Final Boss

Clockwork Castellan Locations in Chapter 16

Where to Find Clockwork Castellan During Your Escape

Map Detailed Location
Map of Clockwork Castellan Detailed Location of Clockwork Castellan

The Clockwork Castellan in Chapter 16 can be found as you make your escape from the island. It's located atop some materials at the back of an area filled with incapacitated enemies. Destroy it with a Handgun or another similar weapon, and then make your getaway.

List of Clockwork Castellan (Doll) Locations


Chapter 15 After Clearing

Village
Chapter 1: Walkthrough Chart: Walkthrough ChartChapter 1 Chapter 2: Walkthrough Chart: Walkthrough ChartChapter 2
Chapter 3: Walkthrough Chart: Walkthrough ChartChapter 3 Chapter 4: Walkthrough Chart: Walkthrough ChartChapter 4
Chapter 5: Walkthrough Chart: Walkthrough ChartChapter 5 Chapter 6Chapter 6
Castle
Chapter 7: Walkthrough Chart: Walkthrough ChartChapter 7 Chapter 8: Walkthrough Chart: Walkthrough ChartChapter 8
Chapter 9: Walkthrough Chart: Walkthrough ChartChapter 9 Chapter 10: Walkthrough Chart: Walkthrough ChartChapter 10
Chapter 11: Walkthrough Guide: Walkthrough GuideChapter 11 Chapter 12: Walkthrough Chart: Walkthrough ChartChapter 12
Island
Chapter 13: Walkthrough Guide: Walkthrough GuideChapter 13 Chapter 14: Walkthrough Guide: Walkthrough GuideChapter 14
Chapter 15: Walkthrough Guide: Walkthrough GuideChapter 15 Chapter 16: Walkthrough Guide: Walkthrough GuideChapter 16
Post Game
Resident Evil 4 RemakeResident Evil 4 Remake Game LengthResident Evil 4 Remake Game Length Clear Rewards and Replay ValueClear Rewards and Replay Value
Replayable Features After ClearingReplayable Features After Clearing
Difficulty Level
Tips and Conditions for Achieving an S+ RankTips and Conditions for Achieving an S+ Rank How to Get S+ Rank: Condition and StrategyHow to Get S+ Rank: Condition and Strategy